Rashmi P. Mohanty is currently an Assistant Professor in the Department of Chemical Engineering at IIT Madras. Her group works at the interface of chemical engineering, synthetic biology, biological engineering, and pharmaceutical sciences to design humanized disease models for effective screening of therapeutic drugs and drug delivery vehicles. Before joining IIT Madras, she worked with Prof. Ron Weiss as a postdoctoral associate in the Biological Engineering Department at the Massachusetts Institute of Technology (MIT), where she used synthetic biology to differentiate engineered human-induced pluripotent stem cells (hiPSCs) into endothelial cells in a spatiotemporally controlled manner toward vascularized organoid formation. She completed her Ph.D. at the College of Pharmacy, University of Texas at Austin (UT), where she worked with Prof. Debadyuti (Rana) Ghosh on developing therapeutic moieties that can overcome the transport barrier of the tumor microenvironment for improved drug delivery. Along with her Ph.D. work, she initiated a project to implement sustainable laboratory practices in biological research labs by reusing and recycling biocontaminated plastic wastes. Prior to matriculation at UT, she completed her Master’s in Chemical Engineering from the Indian Institute of Technology Kanpur, working with Prof. Yogesh M. Joshi on the study of chemical stability of colloidal dispersion of a nano-disc clay, called Laponite. Along with research, she immensely enjoys developing educational content for high school and early undergraduate students, introducing them to scientific research and encouraging them to pursue higher education.
Synthetic biology
Stem cell engineering
Disease modelling
Drug delivery
Extracellular environment
Bio-contaminated plastic micropipette tip sterilization stations: Environmentally, economically, and energetically viable solution
Author: Veyssi, Arian and Samineni, Laxmicharan and Mohanty, Rashmi P.
Magnetized Cellbots to Spatiotemporally Control Differentiation of Human-Induced Pluripotent Stem Cells
Author: 2. Mohanty, R. P.,∗ Mallick, S.,∗ Crowley, P., Sokolich, M., Kiwimagi, K., Razavi, S., Belta, C., Das, S., and Weiss, R.
Year: 2025
Discovery of peptides for ligand-mediated delivery of mRNA lipid nanoparticles to cystic fibrosis lung epithelia
Author: Soto, Melissa R. and Lewis, Mae M. and Leal, Jasmim and Pan, Yuting and Mohanty, Rashmi P. and Veyssi, Arian and Maier, Esther Y. and Heiser, Brittany J. and Ghosh, Debadyuti
Highly effective nanoparticle removal in plant-based water filters
Author: Samineni, Laxmicharan and DeRespino, Sophie and Depaolis, Mekayla and Mohanty, Rashmi P. and Tu, Yu-Ming and Pemmaraju, Sanjana and Velegol, Stephanie and Ghosh, Debadyuti and Kumar, Manish
Effective pathogen removal in sustainable natural fiber Moringa filters
Author: Samineni, Laxmicharan and De Respino, Sophie and Tu, Yu-Ming and Chowdhury, Ratul and Mohanty, Rashmi Prava and Oh, Hyeonji and Geitner, Michael and Alberg, Claire Hartwig and Roman-White, Abigail and McKinzie, Sarine and Lemus, Camila and Massey, Joy and Ghosh, Debadyuti and Truskett, Thomas M. and Velegol, Stephanie and Kumar, Manish
Controlled loading of albumin-drug conjugates ex vivo for enhanced drug delivery and antitumor efficacy
Author: Liu, Xinquan and Mohanty, Rashmi P. and Maier, Esther Y. and Peng, Xiujuan and Wulfe, Steven and Looney, Agnieszka P. and Aung, Kyaw L. and Ghosh, Debadyuti
Identification of peptide coatings that enhance diffusive transport of nanoparticles through the tumor microenvironment
Author: Mohanty, Rashmi P. and Liu, Xinquan and Kim, Jae Y. and Peng, Xiujuan and Bhandari, Sahil and Leal, Jasmim and Arasappan, Dhivya and Wylie, Dennis C. and Dong, Tony and Ghosh, Debadyuti
A Combinatorial Biomolecular Strategy to Identify Peptides for Improved Transport Across the Sputum of Cystic Fibrosis Patients and the Underlying Epithelia
Author: 10. Leal, J., Liu, X., Peng X., Mohanty, R. P., Arasappan, D., Wylie, D., Schwartz, S. H., Fullmer, J. J., McWilliams, B. C., Smyth, H. D. C., and Ghosh, D.